Porcine dynorphin A(1-13) acetate(72957-38-1 free base) 是一种有效的内源性 κ opioid受体激动剂，在生理浓度下具有镇痛作用。暴露于强啡肽 A (1-13) 会导致单个神经元中 [Ca2+]i 的急剧增加，类似于急性 NMDA 治疗所见的增加。

Porcine dynorphin A(1-13) acetate is a potent, endogenous κ opioid receptor agonist and is antinociceptive at physiological concentrations. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment.

Dynorphin A (1-13) exposure (33 μM) causes a significant loss in neuronal viability at 4 h with a visible destruction in neuronal morphology seen at 16 h. Exposure to dynorphin A (1-13) causes acute increases in [Ca2+]i in individual neurons similar to increases seen with acute NMDA treatment. Continuous exposure to dynorphin A (1-13) (100 μM) causes a significant loss of neurons over time[1].

TP1179L

C77H130N24O17

1664

Porcine dynorphin A(1-13) acetate(72957-38-1 free base);Dynorphin A Porcine Fragment 1-13 acetate

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years