BMS-986122 是选择性 μ 阿片受体正变构调节剂，可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用，还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。

BMS 986122 is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC50 = 3 μM).

313669-88-4

C16H15BrClNO3S2

448.78

BMS 986122

DMSO:100mg/mL (222.83mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years