Rottlerin 是一种从Mallotus Philippinensis中得到的天然产物， 是 PKC 的特异性抑制剂，抑制HIV-1整合和狂犬病病毒感染。它通过活化 Caspase 3 诱导细胞凋亡.

Rottlerin is a natural product purified from Mallotus Philippinensis and is a specific PKC inhibitor (IC50: PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM). Rottlerin causes apoptosis via caspase 3 activation.

Rottlerin (20 μM) shows cell proliferation in HMVEC. Rottlerin (20 μM, 2/6/24 hours) dramatically reduces the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC [2].

Rottlerin inhibits tumor cell proliferation and causes apoptosis through activation of caspase-3 and cleavage of the poly polymerase. Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity [3].

82-08-6

C30H28O8

516.54

Mallotoxin;NSC 94525;粗糠柴苦素;NSC 56346

DMSO:2 mg/mL (3.87 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years