Calmidazolium chloride 是一种钙调蛋白拮抗剂，对CaM依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP酶活化有拮抗作用，IC50分别为0.15和0.35 μM。Calmidazolium chloride结合CaMK的Kd值为3 nM。Calmidazolium chloride在抗癌领域有研究的价值。

Calmidazolium chloride is a calmodulin (CaMK) antagonist (Kd = 3 nM), antagonizing CaM-dependent phosphodiesterase(IC50 = 0.15 μM) and calmodulin-induced activation of erythrocyte Ca2+-transporting ATPase(IC50 = 0.35 μM). Calmidazolium chloride also induces apoptosis in certain cancer cell lines.

Calmidazolium chloride also induces apoptosis in certain cancer cell lines. Calmidazolium chloride (3, 5, 7, 10 μM, 30 minutes-24 hours) inhibits the growth of mouse F9 ECCs [2].

57265-65-3

C31H23Cl7N2O

687.7

R 24571;钙调蛋白抑制剂

DMSO:100 mg/mL (145.41 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years