Rimacalib is an inhibitor of Ca2+/calmodulin-dependent protein kinase II (IC50s: ~1 μM for CaMKIIα and ~30 μM for CaMKIIγ).

Higher Fura-2 transient amplitude after the pause upon Rimacalib vs. 37.2±4.3% in control and in parallel cardiomyocyte contractility (135.0±15.4% vs. 97.2±16% increase of twitch amplitude, p=0.098). Rimacalib improves (by ~40%) Ca2+-transient potentiation during the 30 s stimulation pause [1].

215174-50-8

C22H23FN4O2

394.44

SMP 114

DMSO:125 mg/mL (316.90 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years