RegadeNOSon 是一种腺苷衍生物和选择性 A2A 腺苷受体激动剂，具有冠状动脉舒张活性，对大鼠和猪腺苷 A2A 受体的Ki分别为 290 和 1120 nM。它是血管扩张剂，可增加啮齿动物血脑屏障的通透性。

Regadenoson is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and activates the A2A adenosine receptor, which induces coronary vasodilation. This leads to an increase in coronary blood flow and enhances myocardial perfusion. Compared to adenosine, regadenoson has a longer half-life and shows higher selectivity towards the A2A adenosine receptor. This agent is a very weak agonist for the A1 adenosine receptor and has negligible affinity for the A2B and A3 adenosine receptors.

313348-27-5

C15H18N8O5

390.36

CVT-3146;瑞加德松;Lexiscan

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years