PF 6274484 是一种EGFR抑制剂，对于 EGFR-L858R/T790M 和 WT-EGFR 的 Ki 值分别为 0.14 和 0.18 nM。它在 H1975 肿瘤细胞和 A549 肿瘤细胞中抑制EGFR-L858R/T790M自身磷酸化和EGFR-WT，IC50分别为6.6和 5.8 nM。

PF 6274484, a high affinity, irreversible covalent inhibitor of EGFR kinase with Ki of 0.14 nM, inhibits the autophosphorylation of wild-type EGFR in A549 cells and EGFRL858R/T790M in H1975 cells with IC50 of 5.8 nM and 6.6 nM, respectively.

1035638-91-5

C18H14ClFN4O2

372.78

PF 6274484

DMSO:65 mg/ml (174.36 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years