BPR1J-097 hydrochloride (1327167-19-0(free base)) 是一种新型小分子FLT-3抑制剂(IC50=11±7 nM)，具有很好的体内抗肿瘤活性。

BPR1J-097, a new-type small molecule FLT-3 inhibitor(IC50=11±7 nM), is with great anti-tumor activities in vivo.

In FLT3-driven AML murine xenograft models, BPR1J-097 inhibited FLT3/signal transducer and activator of transcription 5 phosphorylation and triggered apoptosis in FLT3-driven AML cells and pronounced dose-dependent tumour growth inhibition and regression.

Cells are treated with THZ531 for 6 hours.After treatment cells are washed 2-fold with cold PBS and then lysed in the following lysis buffer: Hepes(50 mM, pH 7.4), NaCl（150 mM）, 1% Nonidet P40 substitute, EDTA（5 mM）, DTT（1 mM）, and protease/phosphatase cocktails.Lysates are treated with bio-THZ1 or bio-TH531 for pulldown overnight at 4°C.

T4261

C27H29ClN6O3S

553.07

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years