ARRY380 analog 是EGFR (ErbB1)的抑制剂，详情参见专利 WO2015153959A2，化合物 249。

ARRY-380 is a potent and selective HER2 inhibitor.

The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.

937265-83-3

C29H27N7O4S

569.64

ARRY380;HER2-Inhibitor-1;ARRY-380 analog

DMSO:91 mg/mL(159.8 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years