Futibatinib 是口服具有活力的、选择性强的、高生物利用度的、不可逆的FGFR抑制剂。它抑制突变型和野生型 FGFR2，且 IC50相似 (wild-type FGFR2=0.9?nM; V5651=1-3?nM; N550H=3.6?nM; E566G=2.4?nM)。

TAS-120 is a novel, potent and highly selective FGFR inhibitor, used for antitumor treatment.

TAS-120 (3, 30, 100 mg/kg/day, p.o.) exerts an anti-tumor effect in mice. TAS-120 shows anti-tumor effect by administering at moderate intervals, such as intermittent administration of every other day dosing and 2 times/week, and reducing the sustained elevation and weight suppression blood phosphorus level, and take a antitumor effective as daily administration.

1448169-71-8

C22H22N6O3

418.457

TAS120;FGFR-IN-1

DMSO:29 mg/mL (69.30 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years