EGFR-IN-16 是一种EGFR抑制剂，对 EGFR 和 HER-2 的pIC50分别为4.85和4.74。

AG473 is an inhibitor of EGFR in human A431 cells.

Expressed the Ag473 lipoprotein from Neisseria meningitides, flagellin FlaB from Vibrio vulnificus and heat shock protein 70 from Mycobacterium tuberculosis (mHsp70) in Escherichia coli as single proteins and fusion proteins with VP2 protein of infectious bursal disease virus (IBDV).?Both cellular and humoral adjuvanticities of the three TLR ligands were compared by immunization of mice in two different ways.?Among the three co-administered TLR ligands, recombinant Ag473 lipoprotein exhibited the highest cellular and humoral adjuvanticities, including promotion of IL-4, IL-12, IFN-γ and IBDV VP2-specific antibody production.?Among the three genetically fused TLR ligands, fusion with Ag473 D1 domain exhibited the highest cellular and humoral adjuvanticities.

133550-22-8

C16H11NO3

265.26

AG473

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years