N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).

N-piperidine Ibrutinib hydrochloride is a BTK ligand in the synthesis of a series of PROTACs. SJF638, SJF678, and SJF608 are potent degrader of PROTAC BTK(DC50s of 374, 162, and 8.3 nM, respectively)[2].

2231747-18-3

C22H23ClN6O

422.91

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years