SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively).

SB-633825 (0.1 μM) inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity. SB-633825 inhibits TIE2 Tyrosine-protein kinase, lymphocyte-oriented kinase (LOK; STK10), and breast tumor kinase (Brk; PTK6) [1].

956613-01-7

C28H25N3O3S

483.58

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years