Nilotinib monohydrochloride monohydrate 是酪氨酸酶抑制剂，有效抑制Bcr-Abl及其突变体。

Nilotinib monohydrochloride monohydrate is significantly potent BCR-ABL against, is a second generation tyrosine kinase inhibitor (TKI), and is active against many BCR-ABL mutants.

In the indomethacin-induced enterocolitis rat model, nilotinib has a positive effect on the macroscopic and microscopic pathologic scores, ensuring considerable mucosal healing.?Nilotinib decreases PDGFR α and β levels and increases the colonic apoptotic scores[2].

923288-90-8

C28H25ClF3N7O2

584.0

AMN107 (monohydrochloride monohydrate);尼洛替尼盐酸盐一水合物;尼罗替尼中间体;Nilotinib (monohydrochloride monohydrate)

DMSO:33 mg/mL (56.51 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years