(Z)-Guggulsterone 是印度阿育吠陀药用植物Commiphora mukul的成分，可通过引起细胞凋亡来抑制人前列腺癌细胞的生长，还可通过抑制VEGF-VEGF-R2-Akt信号传导轴来抑制血管生成。

(Z)-Guggulsterone inhibits the growth of human prostate cancer cells by causing apoptosis. Z-guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis.

In HUVEC, Z-guggulsterone (10, 20 μM; 24 or 48 hours) induces a reduction in the level of VEGF-R2 protein [1].

In tumor volume and wet tumor weight, Z-guggulsterone (p.o.; 1 mg; 5 times/week) causes a statistically significant reduction [1].

39025-23-5

C21H28O2

312.45

DMSO:10 mg/mL (32.01 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years