TolimIDOne 是选择性的Lyn kinase变构激活剂，其EC50=63 nM。

MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.

In an in vitro broad kinase screen MLR-1023 activated the nonreceptor-linked Src-related tyrosine kinase Lyn. MLR-1023 increased the Vmax of Lyn with an EC50 of 63 nM. This Lyn kinase activation was ATP binding site independent, indicating that MLR-1023 regulated the kinase through an allosteric mechanism[1].

MLR-1023-mediated blood glucose lowering depends on Lyn kinase activity[1]. MLR-1023 is an insulin receptor-potentiating agent that produces a rapid-onset and durable blood glucose-lowering activity in diabetic animals[2].

Adipocyte differentiation is assessed in mouse 3T3-L1 cells after 8 days of incubation with MLR-1023 or rosiglitazone (10 μM).(Only for Reference)

41964-07-2

C11H10N2O2

202.213

托利咪酮;NSC 314335;CP-26154;MLR-1023

DMSO:20.2 mg/mL (100 mM)
Ethanol:4 mg/mL (20 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years