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GSK 690 Hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK 690 Hydrochloride图片
包装与价格:
包装价格(元)
100 mg电议
200 mg电议

产品介绍
GSK 690 (Hydrochloride) 是一种可逆的赖氨酸特异性去甲基化酶1 (LSD1)抑制剂,Kd值为 9 nM,IC50值为 37 nM。

产品描述

GSK 690 (Hydrochloride) is a reversible lysine specific demethylase 1 (LSD1) inhibitor with a Kd value of 9 nM and IC 50 of 37 nM.

体外活性

GSK690 (1-10 μM) acts in concert with JNJ-26481585 to induce cell death in all four tested RMS cells lines (RD, RH30, RMS13, and TE381.T cells) [2]. GSK690/JNJ-26481585 cotreatment alters the balance between pro- and antiapoptotic proteins with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. GSK690/JNJ-26481585 cotreatment induces caspase-dependent cell death with 1 μM GSK690 for RD cells and 10 μM GSK690 for RH30 cells [2]. The addition of GSK690 further enhances the JNJ-26481585-stimulated G2/M arrest [2].

Cas No.

T11503

分子式

C24H24ClN3O

分子量

405.92

储存和溶解度

DMSO:125 mg/mL (307.94 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years