Amodiaquine是一种合成的4-氨基喹啉类抗疟剂,是一种有口服活性的组胺 N-甲基转移酶抑制剂。它也是一种Nurr1激动剂,有抗炎活性,可特异性结合Nurr1的配体结合域,EC50约为20 μM。
产品描述
Amodiaquine is a synthetic aminoquinoline, used to treat malaria.
体外活性
Inflammatory responses are considered to play pivotal roles in the pathogenesis of intracerebral hemorrhage (ICH).?a nuclear receptor Nurr1 (NR4A2) was expressed prominently in microglia/macrophages and astrocytes in the perihematomal region in the striatum of mice after ICH.?Daily administration of a Nurr1 agonist amodiaquine (40 mg/kg, i.p.) from 3 h after ICH induction diminished perihematomal activation of microglia/macrophages and astrocytes.?Amodiaquine also suppressed ICH-induced mRNA expression of IL-1β, CCL2 and CXCL2, and ameliorated motor dysfunction of mice.?These results suggest that Nurr1 serves a novel target for ICH therapy.
Cas No.
86-42-0
分子式
C20H22ClN3O
分子量
355.87
储存和溶解度
DMSO:71 mg/mL (199.52 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years