TTK21 是 CBP/p300 组蛋白乙酰转移酶活性的激活剂，与葡萄糖基碳纳米球结合时，可通过血脑屏障，对成人大脑神经发生和长期记忆功能有益。

TTK21 is an activator of CBP/p300 histone acetyltransferase activity.

a small-molecule (TTK21) activator of the histone acetyltransferases CBP/p300, which, when conjugated to glucose-based carbon nanosphere (CSP), passed the blood-brain barrier, induced no toxicity, and reached different parts of the brain.?After intraperitoneal administration in mice, CSP-TTK21 significantly acetylated histones in the hippocampus and frontal cortex.?Remarkably, CSP-TTK21 treatment promoted the formation of long and highly branched doublecortin-positive neurons in the subgranular zone of the dentate gyrus and reduced BrdU incorporation, suggesting that CBP/p300 activation favors maturation and differentiation of adult neuronal progenitors.?In addition, mRNA levels of the neuroD1 differentiation marker and BDNF, a neurotrophin required for the terminal differentiation of newly generated neurons, were both increased in the hippocampus concomitantly with an enrichment of acetylated-histone on their proximal promoter.

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C17H15ClF3NO2

357.76

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years