Ionomycin calcium是选择性钙离子载体，也是一种由Streptomyces conglobatus产生的抗生素。它对二价阳离子具有高度特异性，还诱导蛋白激酶C激活。Ionomycin促进细胞凋亡。

lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis.

Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells as supported by simultaneously positive fluorescein labeling and propidium iodide uptake. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment.

56092-82-1

C41H72CaO9

749.08

SQ23377 calcium;罗红霉素钙盐(链霉菌属载体)

DMSO:9 mg/mL (12.05 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years