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AS2521780
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS2521780图片
CAS NO:1214726-89-2
包装:5 mg
市场价:9850元

产品介绍

产品描述

AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).

体外活性

AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells and it also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM). Which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases.

体内活性

AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1].

Cas No.

1214726-89-2

分子式

C30H41N7OS

分子量

547.76

储存和溶解度

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years