产品描述
AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).
体外活性
AS2521780 suppresses CD3/CD28-induced Interleukin-2 (IL-2) gene transcription in Jurkat T cells and proliferation of human primary T cells and it also suppresses concanavalin A-induced cytokine production by rat splenocytes and monkey peripheral blood mononuclear cells with similar potency[1]. AS2521780 exerts potent inhibition of recombinant human PKCθ enzyme activity (IC50=0.48 nM). Which is more than 30-fold higher than that of other PKC isoforms. Further, AS2521780 exerts little or no inhibition on other protein kinases.
体内活性
AS2521780 significantly reduces paw swelling in a dose-dependent manner in a rat model of adjuvant-induced arthritis[1].
Cas No.
1214726-89-2
分子式
C30H41N7OS
分子量
547.76
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years