TolreSTAT 是一种有效的醛糖还原酶抑制剂 (IC50 = 35 nM)。

Tolrestat is a potent inhibitor of aldose reductase (IC50 = 35 nM).

The estimated ID in the sciatic nerve and lenses is 4.8 and about 20 for tolrestat, and 1.7 and 2.2 for (±)sorbinil, respectively in diabetic rats[1]. Tolrestat inhibits tissue AR activity but does not significantly affect plasma lipoprotein levels, or affect the body weight of the mice or their general health. Accumulation of cholesterol-rich foam cells is significantly increased in aortic roots of tolrestat-fed mice[2]. Tolrestat (1.8 mg/kg) causes a reversal of normal RBC sorbitol levels[3].

82964-04-3

C16H14F3NO3S

357.35

托瑞司他;AY-27773

DMSO:100 mg/mL (279.84 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years