3,5-DinitroCATechol 是儿茶酚-O-甲基转移酶的有效抑制剂，IC50为 12 nM。它可用于制备钼 (VI)- 3,5-DinitroCATechol 配合物。

OR-486 is an inhibitor of catechol-O-methyl-transferase(COMT) and can be used to prepare the molybdenum (VI)- 3,5-Dinitrocatechol complex.

OR-486 is highly effective (IC50 = 12 nM) and selective in inhibiting COMT activity in vitro[3].

In mouse trachea (β1-AR dominant), significant suppression of ISO-induced relaxation was observed with the addition of OR-486. In GP trachea, in the presence of clorgiline plus OR-486, both normetadrenaline (NMA) and metadrenaline (MA) (10-4 M) significantly suppressed ISO-induced relaxation[1].

7659-29-2

C6H4N2O6

200.11

Ethanol:<20.01mg/mL
DMSO:<20.01mg/ml
H2O:0.17 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years