PHPS1 是Shp2的选择性抑制剂，对 Shp2，Shp2-R362K，Shp1，PTP1B 和 PTP1B-Q 的Ki分别为 0.73，5.8，10.7，5.8 和 0.47 μM。

PHPS1 is an inhibitor of Shp2. PHPS1 efficiently inhibits activation of Erk1/2 by the leukemia-associated Shp2 mutant, Shp2-E76K, and blocks the anchorage-independent growth of a variety of human tumor cell lines.

PHPS1 (30 μM; 6 days) inhibits proliferation of human tumor cells[1]. PHPS1 (5-20 μM; 5-360 minutes) inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner[1].

PHPS1 (3 mg/kg; i.p. injection; every day during the last week on the high-fat diet) renders Ldlr-/- mice less susceptible to atherosclerosis development[2].

314291-83-3

C21H15N5O6S

465.44

PHPS 1;PHPS-1

DMSO:16.25 mg/ml (34.91 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years