MBCQ 是选择性 cGMP 特异性磷酸二酯酶 (PDE V; PDE5) 抑制剂，IC50=19 nM。它通过特异性抑制 cGMP-PDE 来扩张冠状动脉。它对其他 PDE 同工酶没有抑制活性，IC50均大于 100 μM。

MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.

MBCQ, a selective PDE5 inhibitor, significantly decreased the EC(50) values for GTN-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift occurring in tolerant veins[1].

150450-53-6

C16H12ClN3O2

313.74

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years