Gly-β-MCA, a bile acid, is a sable, intestine-selective, and oral bioactive farnesoid X receptor (FXR) inhibitor.

Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH.Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor.

Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation.Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice.

66225-78-3

C26H43NO6

465.62

DMSO:125 mg/mL (268.46 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years