LY2955303 是一种有效的特异性视黄酸受体 γ 拮抗剂（RARγ，Ki = 1.09 nM）。

LY2955303 is an effective and selective antagonist of retinoic acid receptor gamma (RARγ, Ki = 1.09 nM).

The functional Ki for RARγ is 7.1±4.9 nM. The binding Kis of LY2955303 for RARα, RARβ, and RARγ are >1700, >2980, and 1.09 nM, respectively[1].

A single dose of LY2955303(oral) showed a dose-response effect in rats with different weight-bearing reductions with an ED50 of 0.72 mg/kg[1].

1433497-19-8

C36H42N4O3

578.74

DMSO:25 mg/mL (43.20 mM),Need ultrasonic and warming
Powder: -20°C for 3 years
In solvent: -80°C for 2 years