AZD8329 is a potent inhibitor of 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1)(IC50 of 9 nM for human 11β-HSD1), and displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3.

AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively[1].

1048668-70-7

C25H31N3O3

421.53

DMSO:62.5 mg/mL (148.27 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years