Bepridil hydrochloride 是一种钙通道阻滞剂，还抑制 Na+/Ca2+ 交换 (NCX)、钠通道和心脏肌膜 KATP 通道，具有抗心绞痛的作用。

Bepridil is a calcium channel blocker and also inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels.

Bepridil (1-100 microM) inhibited the K(ATP) channel current in a concentration-dependent manner. The IC(50) value of bepridil was estimated to be 10.5 microM for outward K(ATP) channel currents (holding potential, +60 mV) and 6.6 microM for inward K(ATP) channel currents (holding potential, -60 mV). Bepridil (0.1-30 microM) also inhibited K(Na) channel currents measured at the holding potential of -60 mV, in a concentration-dependent manner with an IC(50) value of 2.2 microM [2].

The predominant effects of Bepridil (cumulative dose = 9.0 mg/kg i.v.) in the conscious rat were reduced coronary vascular resistance and heart rate. Bepridil showed selectivity for the coronary circulation since systemic vascular resistance was not significantly reduced until cumulative i.v. dosage of 21.0 mg/kg was administered [1].

68099-86-5

C24H35ClN2O

403.01

CERM 1978;盐酸苄普地尔

DMSO:130 mg/mL (322.58 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years