SRPKIN-1 is a covalent and irreversible inhibitor of SRPK1/2 (IC50s: 35.6 and 98 nM, respectively).

SRPK-IN-1 effectively converts VEGF from pro-angiogenic to anti-angiogenic isoform. SRPKIN-1 treatment at 200 nM (10, 50, 100, 200 nM, 16 hours) obviously decreases SR protein phosphorylation at the steady-state with or without washout [1].

SRPKIN-1 (50 nM, 300 nM,1 μL, 5 times) blocks angiogenesis through VEGF alternative splicing in a CNV mouse model [1].

2089226-94-6

C27H21FN2O3S

472.53

DMSO:110 mg/mL (232.79 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years