YH239-EE 是 YH239 的乙酯，是 p53-Mdm2 拮抗剂和凋亡诱导剂。

YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.

YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). [1]

Cell lines are harvested in log-phase growth and seeded following exposure to p53-MDM2 antagonists. Cell number and viability are determined by staining cells with Trypan blue 0.4% and counted with Countess slides.(Only for Reference)

1364488-67-4

C25H27Cl2N3O4

504.41

H2O:<1 mgml
Ethanol:15 mg/mL (29.7 mM)
DMSO:93 mg/mL (184.4 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years