IQ-1S 是NF-Κb/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。

IQ-1S is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH.

23146-22-7

C15H9N3O

247.257

IQ-1S (free acid);IQ-1;IQ-1S

DMSO:32 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years