IQ3 是c-JNK家族选择性抑制剂，对JNK3 的选择性更好。它对JNK1、JNK2 和 JNK3 的Kd值分别为0.24 μM、0.29 μM 和 0.066 μM。

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-κB/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 μM, also inhibits TNF-α and IL-6 production in vitro.

312538-03-7

C20H11N3O3

341.326

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years