| CAS NO: | 838818-26-1 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 521.59 |
|---|---|
| Formula | C29H23N5O3S |
| CAS No. | 838818-26-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 7 mg/mL (13.4 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 2-(3-((4-(4-methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)propyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione InChi Key: RNUXIZKXJOGYQP-UHFFFAOYSA-N InChi Code: InChI=1S/C29H23N5O3S/c1-37-22-11-9-21(10-12-22)34-26(20-13-15-30-16-14-20)31-32-29(34)38-18-4-17-33-27(35)23-7-2-5-19-6-3-8-24(25(19)23)28(33)36/h2-3,5-16H,4,17-18H2,1H3 SMILES Code: O=C(NC1=CC=CC=C1C(NC2=CC=C(CCN3CC4=C(C=C(OC)C(OC)=C4)CC3)C=C2)=O)C5=CC=C(OC)C(OC)=C5 |
| Synonyms | WIKI4; WIKI 4; WIKI-4 |
| In Vitro | In vitro activity: WIKI4 inhibitsWnt/ss-catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ss-catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins. Kinase Assay: WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2, and leads to inhibition of Wnt/beta-catenin signaling. Cell Assay: WIKI4 inhibits expression of β-catenin target genes and cellular responses to Wnt/β-catenin signaling in cancer cell lines as well as in human embryonic stem cells. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | PLoS One. 2012;7(12):e50457. |
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