9-Phenanthrol 是瞬时受体电位 melaSTATin 4 (TRPM) 通道的抑制剂，这是一种 Ca2+ 激活的非选择性阳离子通道。

9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.

In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5[1].

484-17-3

C14H10O

194.23

Ethanol:9mg/mL (46.34mM）,Need ultrasonic
DMSO:19mg/mL (97.82mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years