Ononetin 是天然脱氧安息香素，是有效的TRPM3 通道选择性阻断剂，IC50为 0.3 μM。

Ononetin is a TRPM3 channel blocker(IC50: 0.3 μM).

Administration of 1-10 μM Ononetin completely and reversibly abrogates Ca2+ entry and ionic currents through recombinantly expressed TRPM3α2 and block the pregnenolone sulphate-inducible Ca2+ entry in primary cultures of mouse or rat dorsal root ganglia (DRG) neurones[1].

Intraperitoneal injection of 10 mg/kg Ononetin completely reverses established Freund's Complete Adjuvant (FCA)-induced heat hypersensitivity, demonstrating that the loss of hypersensitivity in Trpm3-/- mice is unlikely to be caused by developmental or compensatory mechanisms[2].

487-49-0

C15H14O4

258.27

2',4'-Dihydroxy-2-(4-methoxyphenyl)acetophenone;芒柄花酚

DMSO:<30mg>Ethanol:<30mg>Powder: -20°C for 3 years
In solvent: -80°C for 2 years