ASP7663 是口服有效的TRPA1选择性激动剂。ASP7663具有抗便秘和抗腹痛的功效。

ASP7663 is a TRPA1 Receptor Agonist and exhibiting an abdominal analgesic effect in vivo.

ASP7663, a novel and selective TRPA1 agonist, in constipation models as well as an abdominal pain model.?ASP7663 activated human, rat, and mouse TRPA1 and released 5-HT from QGP-1 cells, and oral but not intravenous administration of ASP7663 significantly improved the loperamide-induced delay in colonic transit in mice.?While pretreatment with the TRPA1 antagonist HC-030031 and vagotomy both inhibited the ameliorating effect of oral ASP7663 on the colonic transit, both orally and intravenously administered ASP7663 significantly inhibited colorectal distension (CRD)-induced abdominal pain response in rats[1].

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C14H14FNO3

263.268

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years