Cyclo(RGDyK) 是一种选择性αVβ3整联蛋白抑制剂，IC50为 20 nM。

Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]

In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]

250612-42-1

C31H45F6N9O12

849.742

Cyclo(RGDyK)

DMSO:130 mg/mL(153.35 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years