| CAS NO: | 1256493-34-1 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 338.31 |
|---|---|
| Formula | C18H14N2O5 |
| CAS No. | 1256493-34-1 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 67 mg/mL (198.0 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name:
3-Hydroxynaphthalene-2-carboxylic acid 2-[(2,4,5-trihydroxyphenyl)methylene]hydrazide InChi Key: UAXHPUSKEWEOAP-DJKKODMXSA-N InChi Code: InChI=1S/C18H14N2O5/c21-14-8-17(24)16(23)7-12(14)9-19-20-18(25)13-5-10-3-1-2-4-11(10)6-15(13)22/h1-9,21-24H,(H,20,25)/b19-9+ SMILES Code: O=C(C1=C(O)C=C2C=CC=CC2=C1)N/N=C/C3=CC(O)=C(O)C=C3O |
| Synonyms | Dyngo-4a; Dyngo 4a; Hydroxy Dynasore; Dyngo4a; |
| In Vitro | In vitro activity: Dyngo-4a inhibits dynamin-dependent endocytosis of transferrin in multiple cell types with IC50 of 5.7 μM, and reduces synaptic vesicle endocytosis and activity-dependent bulk endocytosis in cultured neurons and synaptosomes. In motor nerve terminals and cultured hippocampal neurons, Dyngo-4a blocks Alexa Fluor 488-BoNT/A-Hc internalization. In Drosophila S2R+ cells, Dyngo-4a causes a decrease in the level of Armadillo/β-catenin. Cell Assay: Dyngo-4a (100 μM) caused a reduction in β-catenin levels in human colon carcinoma RKO cells. In addition, Dyngo-4a prevented the uptake of BoNT/A-Hc and blocked BoNT/A-induced SNAP25 cleavage in cultured hippocampal neurons. Dyngo-4a is potent, reversible endocytosis inhibitor in non-neuronal cells. Dyngo-4a inhibited synaptic vesicle endocytosis (SVE) in synaptosomes and neurons with an IC50 value of 26.8 μM. |
|---|---|
| In Vivo | Dynamin is a potential therapeutic target for counteracting botulism. Dyngo-4a (30 mg/kg, intraperitoneal injection) treatment suppressed BoNT/A-induced muscle paralysis at the rat hemidiaphragm and significantly delayed the onset of botulism in an in vivo murine model. |
| Animal model | Murine |
| Formulation & Dosage | 30 mg/kg, intraperitoneal injection |
| References | Traffic. 2013 Dec;14(12):1272-89; J Cell Sci. 2014 Nov 15;127(Pt 22):4918-26. |
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