DRB 是一种核苷类似物，对几种羧基末端结构域激酶（包括酪蛋白激酶 II 、细胞周期依赖性激酶）有抑制作用。它可诱导人类结肠腺癌细胞的 p53 依赖性凋亡，且不会诱发健康细胞遗传毒性应激。

DRB is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II (IC50 range of 4-10 μM)

DRB can inhibit HIV transcription (IC50 = ~4 μM) by targeting elongation enhanced by the HIV-encoded transactivator Tat[1].

53-85-0

C12H12Cl2N2O4

319.14

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years