4-Phenoxybenzylamine 通过稳定无活性构象来抑制NS3蛋白的功能,对 HCV NS3/4a 的 IC50 约为 500 μM。
产品描述
4-Phenoxybenzylamine inhibits the function of the NS3 protein by stabilizing an inactive conformation with an IC50 of about 500 μM against HCV NS3/4a .
体外活性
A highly conserved novel binding site located at the interface between the protease and helicase domains of the Hepatitis C Virus (HCV) NS3 protein is identified. 4-Phenoxybenzylamine binding at this allosteric site inhibits the function of the NS3 protein by stabilizing an inactive conformation therefore it represents a new class of direct-acting antiviral agents.
Cas No.
107622-80-0
分子式
C13H13NO
分子量
199.253
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years