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Ethynyl estradiol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ethynyl estradiol图片
CAS NO:57-63-6
包装与价格:
包装价格(元)
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
17α-Ethynylestradiol
炔雌醇
Ethinyl Estradiol
乙炔基雌二醇
产品介绍
Ethynyl Estradiol 是一种高效的生物活性雌激素。

产品描述

Ethinyl estradiol is a semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.

体外活性

Ethinyl Estradiol increases respiratory chain activity in both cultured rat hepatocytesand HepG2 cells. Ethinyl estradiol is a strong promoter of hepatocarcinogenesis. [1] Ethinyl Estradiol enhances the transcript levels of nuclear genome- and mitochondrial genome-encoded genes and respiratory chain activity in female rat liver, and also inhibits transforming growth factor beta (TGFbeta)-induced apoptosis in cultured liver slices and hepatocytes from female rats. Ethinyl Estradiol increases the transcript levels of the mitochondrial genome-encoded genes cytochrome oxidase subunits I, II, and III in cultured female rathepatocytes. Ethinyl Estradiol significantly increases both the levels of glutathione (reduced [GSH] and oxidized [GSSG] forms) per mg protein in mitochondria and nuclei, while the percentage of total glutathione in the oxidized form is not affected. [2]

体内活性

Ethinyl Estradiol (50 mg/kg/day) increases anogenital distance and reduces pup body weight at postnatal day 2, accelerates the age at vaginal opening, reduces F1 fertility and F2 litter sizes, and induces malformations of the external genitalia (5 mg/kg) in the female Long-Evans rat. [3] Ethinyl Estradiol increases the number of low density lipoprotein (LDL) receptors in livers of rats, thereby producing a profound fall in plasma cholesterol levels. Ethinyl Estradiol exerts the same effect in livers of male and female rabbits and that the increase in receptor number is correlated with a 6- to 8-fold increase in the levels of receptor mRNA. [4]

Cas No.

57-63-6

分子式

C20H24O2

分子量

296.41

别名

17α-Ethynylestradiol;炔雌醇;Ethinyl Estradiol;乙炔基雌二醇

储存和溶解度

Ethanol:55 mg/mL (185.6 mM)
DMSO:55 mg/mL (185.6 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years