DSRM-3716 是选择性的SARM1 NADase抑制剂,IC50为 75 nM,相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。
产品描述
Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.
体外活性
Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner[1].
Cas No.
58142-99-7
分子式
C9H6IN
分子量
255.06
储存和溶解度
DMSO:50 mg/mL (196.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years