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DSRM-3716
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:58142-99-7
包装与价格:
包装价格(元)
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品介绍
DSRM-3716 是选择性的SARM1 NADase抑制剂,IC50为 75 nM,相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。

产品描述

Isoquinoline, 5-iodo- (9CI) is a potent and selective inhibitor of SARM1(IC50 = 75 nM) by preventing axonal degeneration and by allowing functional recovery of a metastable pool of damaged, but viable, axons.

体外活性

Treatment with the isoquinoline Isoquinoline, 5-iodo- (9CI) produced dose-dependent inhibition of cADPR increase (IC50 = 2.8 μM) and substantial preservation of NAD+ in these cultures in a manner consistent with engagement and inhibition of SARM1 enzymatic NADase activity inside the cells. Isoquinoline, 5-iodo- (9CI) prevented NfL release from severed axons in a dose-dependent manner[1].

Cas No.

58142-99-7

分子式

C9H6IN

分子量

255.06

储存和溶解度

DMSO:50 mg/mL (196.03 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years