MMP-3 Inhibitor 是一种细胞渗透性强的人 MMP-3 抑制剂.
产品描述
MMP-3 Inhibitor is a cell-permeable and potent inhibitor of human MMP-3.
体外活性
MMP3 inhibitor 1 (Compound 27) inhibits MMP-1, MMP-2, MMP-9, and MMP-14 with IC50s of 14000, 529, 2420, and 20100 nM, respectively[1].
体内活性
MMP-3 Inhibitor is a cell-permeable p-methoxysulfonamido D-leucine containing hydroxamate compound that acts as a potent inhibitor of human MMP-3 (stromelysin; Ki = 23 nM) and murine macrophage metalloelastase (MME/MMP-12; IC50 = 13 nM). Binds to the MMP active site Zn2+ [2] [3].
Cas No.
T37048L
分子式
C29H50N10O11S
分子量
746.83
别名
MMP-3 Inhibitor acetate(158841-76-0 Free base)
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years