S 3304 是一种新型的基质金属蛋白酶抑制剂，能够特异的抑制MMP-2和MMP-9的活性。

S 3304 is a novel matrix metalloproteinases inhibitor which is specific for MMP-2 and MMP-9.

S 3304 is a novel D-tryptophan derivative and a potent, noncytotoxic Matrix metalloproteinases inhibitor. S 3304 most effectively inhibits the activities of MMP-2 and MMP-9 but does not inhibit MMP-1, MMP-3, or MMP-7 and may, therefore, lack the musculoskeletal side effects seen with nonspecific inhibitors [1].

S 3304 (p.o., the dose range of 20 to 200 mg/kg) treatment, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 cause effective inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen [1].

203640-27-1

C24H20N2O4S2

464.56

DMSO:83.3 mg/mL (179.31 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years