ZK824190 是具有口服活性尿激酶型纤溶酶原激活剂 (uPA) 选择性抑制剂，对 uPA，tPA 和 Plasmin 的IC50分别为 237，1600 和 1850 nM。ZK824190在多发性硬化症中有研究价值。

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.

In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h[1].

2254001-81-3

C22H20F2N2O4

414.4

DMSO:12 mg/ml (28.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years