K-80003 is a potent inhibitor of cancer cell growth and tRXRα-dependent Akt activation.

Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization.

K-80003 has high affinity to RXRα but lacks COX inhibitory activity.K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals.

1292821-90-9

C22H21FO2

336.4

TX-803

DMSO:30 mg/mL (89.18 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years