SYN1143 是人 RON 和 c-Met 的有效抑制剂。体外激酶测定表明SYN1143 对人 RON 和 c-Met 的IC50 分别为 9 和 4 nmol/L。

AMG-1 is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.

913376-84-8

C31H29FN4O5

556.58

AMG-1;RON-IN-1

DMSO:90 mg/mL (161.7 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years