CH7057288 是选择性TRK抑制剂。

CH7057288 is an effective and selective TRK inhibitor with an IC50 value of 1.1 nM, 7.8 nM and 5.1 nM for TRKA, TRKB and TRKC, respectively.

CH7057288, a potent and selective TRK inhibitor belonging to a novel chemical class.CH7057288 induced regression of intracranial tumors and greatly improved event-free survival in an intracranial implantation model mimicking brain metastasis.

2095616-82-1

C32H31N3O5S

569.68

DMSO:34 mg/mL (59.68 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years