PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.

In the FP and PX assay, PF-06733804 inhibits hERG with IC50s of 79 μM and 88 μM, respectively.

1873373-33-1

C20H19F5N4O4

474.38

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years